Specifications/Features
Specificity: Recognizes human CD16, a 50-65kD cell surface molecule, which is the low affinity receptor for IgG (FcR III). CD16 exists as a transmembranous form (Fc gammaRIIIA, or CD16A) and a glycosyl phosphatidylinositol (GPI) anchored form (Fc gammaRIIIB, or CD16B). CD16A is expressed by NK cells, some T cells, and macrophages, whereas CD16B is primarily expressed by granulocytes. In addition, CD16B exists as two allelic variants NA1 and NA2. Recognizes all polymorphonuclear cells irrespective on their NA phenotype. Studies show that the Recognizes an epitope in the first membrane-distal domain of Recognizes both CD16A and CD16B